In patients with mild COPD, there were also lower exercise capacity and gas exchange alterations, with significant differences from controls.
These alterations were also seen in mild COPD and progressed with increasing severity of the obstruction.Ĭonclusion: The main findings of this study in COPD patients residing at high altitude were a progressive decrease in exercise capacity, increased dyspnea, dynamic hyperinflation, restrictive mechanical constraints, and gas exchange abnormalities during exercise, across GOLD stages 1–4. In COPD patients, Pa O 2 and saturation decreased, and delta IC ( p = 0.004) and VT/IC increased ( p = 0.002). Compared with controls, COPD patients had lower V O 2 and VE ( p < 0.001) and higher VE/V CO 2 ( p = 0.001), A-aPO 2, and V D/V T ( p < 0.001). Results: Eighty-one controls and 525 patients with COPD aged 67.5 ± 9.1 years were included.
For the comparison of the variables between the control subjects and the patients according to the GOLD stages, the non-parametric Kruskal–Wallis test or the one-way analysis of variance test was used. Methods: Measurement during a cardiopulmonary exercise test of oxygen consumption (V O 2), minute ventilation (VE), tidal volume (VT), heart rate (HR), ventilatory equivalents of CO 2 (VE/V CO 2), inspiratory capacity (IC), end-tidal carbon dioxide tension (PETCO 2), and ABG. Our objective was to compare exercise capacity, gas exchange, ventilatory alterations, and symptoms in COPD patients at the altitude of Bogotá (2,640 m), of all degrees of severity. Most of the studies evaluating ventilation and arterial blood gas (ABG) during exercise in COPD patients have been conducted at sea level and in small populations of people ascending to high altitudes.
At altitude, the barometric pressure (BP) decreases, and therefore the inspired oxygen pressure and the partial pressure of arterial oxygen (Pa O 2) also decrease in healthy subjects and even more in patients with COPD. 2Faculty of Medicine, Universidad de La Sabana, Bogotá, Colombiaīackground: Exercise intolerance, desaturation, and dyspnea are common features in patients with chronic obstructive pulmonary disease (COPD).1Pulmonary Function Testing Laboratory, Fundación Neumologica Colombiana, Bogotá, Colombia.Mauricio Gonzalez-Garcia 1,2* Margarita Barrero 1 Dario Maldonado 1
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